Benzeneacetamide, N-(2-hydroxyethyl)-alpha-methyl-4-(2-methylpropyl)-
Aminoprofen
CAS: 83394-44-9
Molecular Formula: C15H23NO2
Benzeneacetamide, N-(2-hydroxyethyl)-alpha-methyl-4-(2-methylpropyl)- - Names and Identifiers
| Name | Aminoprofen |
| Synonyms | Aminoprofen N-(beta-Hydroxyethyl)-DL-2-(4'-isobutylphenyl)propionamide N-(2-Hydroxyethyl)-alpha-methyl-4-(2-methylpropyl)benzeneacetamide Benzeneacetamide, N-(2-hydroxyethyl)-alpha-methyl-4-(2-methylpropyl)- |
| CAS | 83394-44-9 |
Benzeneacetamide, N-(2-hydroxyethyl)-alpha-methyl-4-(2-methylpropyl)- - Physico-chemical Properties
| Molecular Formula | C15H23NO2 |
| Molar Mass | 249.352 |
| Physical and Chemical Properties | White waxy crystal, melting point 36-38 ℃. |
Benzeneacetamide, N-(2-hydroxyethyl)-alpha-methyl-4-(2-methylpropyl)- - References
| use | anti-inflammatory and analgesic, its effect is better than ibuprofen, has no irritating effect on gastrointestinal tract, and is well tolerated. |
| production method | method 1: dissolve ibuprofen in benzene and slowly add dichlorosulfoxide under stirring. After adding, continue to stir, and then return. The remaining dichlorosulfoxide and benzene were steamed under reduced pressure below 40°C. Then add benzene to the residual liquid, stir well, and then concentrate to dry under reduced pressure to obtain yellow oily 2-(4-isobutylphenyl) propionyl chloride. Mix anhydrous potassium carbonate and 2-aminoethanol and cool to 5°C. Slowly add 2-(4-isobutylphenyl) propionyl chloride dropwise under stirring to maintain a temperature not exceeding 20°C. After adding, continue to stir, and then react at 75°C. Cooling, adding water, extracting with ether. The extract was washed twice with water, 20% sodium hydroxide solution and 4mol/L hydrochloric acid to remove unreacted ibuprofen and aminoethanol, and finally washed with water until neutral and dried. Concentrate and add amingprofen seeds to the remaining oily viscous. The product solidifies into white waxy crystal amingprofen with a melting point of 36~38 ℃. Method 2:100g ibuprofen and 400ml aminoethanol were refluxed for 24h. Add ether and salt water, and separate the organic layer to obtain ammonia ibuprofen. Or ibuprofen and aminoethanol in carbon tetrachloride, under the action of triethylamine and triphenylphosphine. Amingprofen can also be obtained by reacting at room temperature. |
Last Update：2024-04-09 21:11:58
